The ASH teaching cases are designed as a resource for medical students and hematology instructors. These interactive cases emphasize standard approaches to classic hematologic problems. They are designed to simulate the steps involved in diagnosing a patient, from taking the history and performing a physical exam, to ordering and interpreting lab tests, to making a final diagnosis and following the clinical course of the disease. While working through each case, students are challenged to consider the right questions to ask at each step in the process. Each case has a set of teaching points and a bibliography with links to references.

Educators may link to, reference, or bookmark cases that serve their needs in teaching, provided the links do not use the trademarks of the American Society of Hematology (ASH). To link to a case, use the URL for the first page of the case.

Bleeding Disorders

Bleeding History in a Child Undergoing Surgery (Spero R. Cataland, MD, and Eric H. Kraut, MD)
A 10-year-old Caucasian male is to undergo an elective tonsillectomy.

GI Bleeding (David Green, MD, PhD)
A 51 y/o woman who is scheduled for a bowel resection presents with GI bleeding.

Hematemesis (Marc J. Kahn, MD)
A 64 y/o man presents to the emergency department after four episodes of vomiting.

Surgical Bleeding (Lisa Arfons, MD and Alvin Schmaier, MD)
A 62-year-old female is in the recovery room after a thrombectomy. Her attending is concerned about the amount of blood draining from her chest tubes.

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Bone Marrow Disorders

Fatigue, Dyspnea and Abnormal Blood Counts (Katherine Walsh, MD and Eric Kraut, MD)
A 45-year-old woman presents with complaints of marked fatigue and progressive dyspnea on exertion.

Fever and Petechiae in an Infant (James Harper, MD)
A 17-month-old male is admitted to the hospital with a two week history of fever (T max 104) and a two day history of rash on his legs.

Fever, Cough, Back Pain and Fatigue (Robert A. Kyle, MD, and Michael Tomasson, MD)
A 65-year-old woman developed progressive fatigue approximately 6 months ago and is now admitted with a sudden onset of fever, shaking chills and productive cough.

Macrocytosis (Emmanuel C. Besa, MD)
A 78 y/o woman presents with macrocytosis and fatigue.

A Patient with Pancytopenia (Dr. Peter Marks, MD)
A 34-year-old female is referred to the Emergency Department after seeing her dentist for bleeding gums and is found to have pancytopenia.

Polycythemia (Virginia C. Broudy, MD)
A 72 y/o man comes in for evaluation of polycythemia.

Unexplained Leukocytosis in an Adult (Eileen Scigliano, MD)
A 50 y/o man presents with leukocytosis, a "left shift," thrombocytosis, and basophilia.

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Lymphoproliferative Disorders

Fever, Night Sweats and Weight Loss (Peter W. Marks, MD )
A 27-year-old female seeks medical attention because she has been having fevers accompanied by drenching night sweats over the past month, during which time she has been losing weight.

Lymphadenopathy (Jorge E. Romaguera, MD)
A 60 y/o man complains of a new lump in the right groin for the past two weeks.

Lymphocytosis (Bernard Greenberg, MD)
A 69 y/o white man who is scheduled for a routine herniorrhaphy must cancel because of an abnormal preoperative blood count.

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Platelet Disorders

Thrombocytopenia (Terry Gernsheimer, MD and Michele B. Frank, MD)
A 23 y/o female complains of a rash on her ankles and shins and easy bruising.

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Red Cell Disorders

Abdominal Pain and Anemia in a Child (Allison King, MD, MPH and John DiPersio, MD, PhD)
A 4 y/o male with Hemoglobin SS is admitted to the hospital with abdominal pain and fever.

Anemia (Paul K. Schick, MD)
A 45 y/o white female presents with weakness, dyspnea, and menorrhagia.

Anemia and Hashimoto Thyroiditis (Caroline Cromwell, MD and Marc J. Kahn, MD, MBA)
A 29-year-old woman with a history of Hashimoto thyroiditis presents with shortness of breath, fatigue and jaundice.

Anemia and Jaundice in a Newborn (Charles T. Quinn, MD)
A 7-day-old Caucasian girl is referred to you to determine whether her jaundice is caused by a blood disorder.

Anemia and Thrombocytopenia (Shirley P. Levine, MD)
A 32 y/o African-American woman presents with anemia and thrombocytopenia.

Fatigue, Dyspnea and Abnormal Blood Counts (Katherine Walsh, MD and Eric Kraut, MD)
A 45-year-old woman presents with complaints of marked fatigue and progressive dyspnea on exertion.

Thrombosis and Anemia (Alvin H. Schmaier, MD)
A 27-year-old African-American woman notices the sudden onset of chest pain, shortness of breath, cough, and palpitations while riding on a bus.

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Thrombotic Disorders

Anemia and Thrombocytopenia (Shirley P. Levine, MD)
A 32 y/o African-American woman presents with anemia and thrombocytopenia.

Fatigue, Dyspnea and Abnormal Blood Counts (Katherine Walsh, MD and Eric Kraut, MD)
A 45-year-old woman presents with complaints of marked fatigue and progressive dyspnea on exertion.

Thrombosis (Thomas G. DeLoughery, MD)
A 20 y/o female presents with an extensive deep venous thrombosis.

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Many of these cases were originally developed for use at the authors’ institutions, and ASH thanks these authors for making their cases available to a much wider audience. Members of the ASH Committee on Educational Affairs review each case before it is posted online.

All teaching cases are copyright of the American Society of Hematology. ISSN: 1931-6860.

Have a question or comment about the ASH Teaching Cases? Please e-mail webmaster@hematology.org.