Terry Gernsheimer, MD, and Michele B. Frank, MD

Dr. Gernsheimer: Puget Sound Blood Center and University of Washington School of Medicine, Seattle, WA
Dr. Frank: Cascade Cancer Center, Kirkland, WA

Copyright of the American Society of Hematology, 2006. ISSN: 1931-6860.

This case was reviewed and updated in January 2011 by Dr. Alvin H. Schmaier and members of the Teaching Cases Subcommittee.


Aster RH. Drug-induced immune cytopenias. Toxicology. 2005;209:149-153.

Arepally GM, Ortel TL.Heparin-induced thrombocytopenia. N Engl J Med. 2006;355:809-817.

Bussel J. Treatment of immune thrombocytopenic purpura in adults. Seminars in Hematology 2006; 43(suppl 5):S3-S10.

George JN, Aster RH.Drug-induced thrombocytopenia: pathogenesis, evaluation, and management. Hematology 2009: American Society of Hematology Program Book. 2009; pp153-159.

George JN.Management of immune thrombocytopenia-something old, something new. N Engl J. Med. 2010; 363(20):1959-61.

Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol 2003; 120:574.

Kuter DJ, Gernsheimer TB.Thrombopoietin and platelet production in chronic immune thrombocytopenia. Hematol Oncol Clin North Am. 2009: 23:1193-1211.

Kuter DJ, Rummel M, Boccia R, Macik BG, Pabinger I, Selleslag D, Rodeghiero F, Chong BH, Wang X, Berger DP.Romiplostim or standard of care in patients with immune thrombocytopenia. N. Eng J. Med. 2010; 363(20):1889-99.

Neunert C, et al.Clinical guideline update on "Immune thrombocytopenia: an evidence based practice guideline developed by the American Society of Hematology". Blood. 2011 02 16.

Provan D, et al.International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010;115:168-186.

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