Bernard Greenberg, MD

University of Connecticut Health Center, Farmington, CT

Copyright of the American Society of Hematology, 2006. ISSN: 1931-6860.

This case was reviewed and updated in August 2011 by Dr. Alvin Schmaier and members of the Teaching Cases Subcommittee.


What differential diagnosis should be considered in this case? Review the patient’s information so far, including the patient presentation, history, and physical exam. Consider each of the following and click on the most likely options.

Clonal disorders
Hairy Cell Leukemia (HCL)
Waldenström's Macroglobulinemia
Chronic CML Leukemia (CML)
Chronic Lymphocytic Leukemia (CLL)
Acute Lymphocytic Leukemia (ALL)
Drug Reaction
Infections, such as:
  • Epstein-Barr Virus (EBV)
  • Cytomegalic virus
  • Infectious mononucleosis
  • Brucella
Systemic Lupus Erythematosis (SLE)

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