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Lymphocytosis

Bernard Greenberg, MD

University of Connecticut Health Center, Farmington, CT

Copyright of the American Society of Hematology, 2006. ISSN: 1931-6860.

VI. PROGNOSIS/CLINICAL COURSE

Proceed to Staging: There are 2 staging systems in general use for CLL. Using the Rai classification system, what is the patient's present stage?

Rai

Rai Classification
StageDescriptionMedian Survival
(Years)
Olymphocytosis > 5,000/mL
Bone marrow infiltration >40%
>12
IAs in O, plus adenopathy10
IIAs in O or I, plus splenomegaly and/or hepatomegaly8
IIIAs in O, I or II, plus anemia (Hb < 11gm%)2
IVAs in O, I, II or III, plus thrombocytopenia
(platelets < 100,000/µL)
2

O
I
II
III
IV

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