Lymphocytosis

Bernard Greenberg, MD

University of Connecticut Health Center, Farmington, CT

Copyright of the American Society of Hematology, 2006. ISSN: 1931-6860.

This case was reviewed and updated in August 2011 by Dr. Alvin Schmaier and members of the Teaching Cases Subcommittee.

VI. PROGNOSIS/CLINICAL COURSE

Proceed to Staging: There are two staging systems in general use for CLL. Using the Rai classification system, what is the patient's present stage?

Rai

Rai Classification
Stage Description Median Survival
(Years)
O Lymphocytosis > 5,000/µL
Bone marrow infiltration >40%		 >12
I As in O, plus adenopathy 10
II As in O or I, plus splenomegaly and/or hepatomegaly 8
III As in O, I or II, plus anemia (Hb < 11gm%) 2
IV As in O, I, II or III, plus thrombocytopenia
(platelets < 100,000/µL)		 2

O
I
II
III
IV

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