Fatigue, Dyspnea and Abnormal Blood Counts

Katherine Walsh, MD and Eric Kraut, MD

Ohio State University

Copyright of the American Society of Hematology, 2013. ISSN: 1931-6860.

V. PATHOPHYSIOLOGY

Which of the following are features of the pathophysiology of PNH?
Loss of GPI (glycosylphosphatidylinositol-linked proteins)
Overexpressed GPI-linked proteins
Increased sensitivity to complement
Decreased sensitivity to complement
Mutation in the PIG-A gene
Increased fragility of RBCs in an acidic environment


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