Myeloproliferative Disorder

Eileen Scigliano, MD

Mount Sinai School of Medicine, New York, NY

Copyright of the American Society of Hematology, 2006. ISSN: 1931-6860.

This case was reviewed and updated in March 2013 by Dr. Marc J. Kahn and members of the Teaching Cases Subcommittee.

I. HISTORY

PATIENT PRESENTATION

A 50-year-old man presents with a two-month history of fatigue and early satiety. He comes to your office with a CBC obtained a week prior at an urgent care center. Results of the CBC are shown:

WBC

75,000/µL (normal range: 4,000-10,000/µL)

Hgb

14 g/dL (normal range: 14-16.5 g/dL)

Hct

42% (normal range: 42%-50%)

MCV

88 fl (normal range: 80-96 fl)

Platelets

550,000/µL (normal range: 150,000-400,000/µL)

Differential:

Segmented neutrophils (granulocytes)

33,000/µL (normal range: 1,800-7,000/µL) 

Bands

1,500/µL (normal range: 0-700/µL)

Metamyelocytes

11,000/µL (normal: 0)

Myelocytes

7500/µL (normal: 0)

Basophils

3,750/µL (normal range: 0-200/µL)

Lymphocytes

3,000/µL (normal range 1,000-4,800/µL)

Monocytes

750/µL (normal range 0-800/µL)

What are the hematologic abnormalities present here?

Granulocytosis
Anemia
Thrombocytosis
Normal differential
Basophilia

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